?????? ????? ?????? ???? ??? ????? ???? ??????? ??? ?? ???? ?????? ???????? ???????? ?????? ?????? ??? ????????? ??????? ??? ????????? ????????? ?????? ??? ???? ??? ?? ????? ???? ??????? ???????? ????? ?????? ?????? ?????? ?? ?????? ??????????? ????? ???????? ???? ?????? ????????.four.eight Undesirable consequences Summary of the safety profile In